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Lovastatin
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  • Yung Shin Pharmaceutical Industry Ltd., 20 MG Tablet Oral 40 MG Tablet Oral 10 mg/1 Tablet Oral 20 mg/1 Tablet Oral 40 mg/1 Tablet Oral 21 mg

    Prices

    Unit description Cost Unit
    Altoprev 60 mg 24 Hour tablet 7.,99USD tablet
    Altoprev 60 mg tablet 7.74USD tablet
    Altoprev 20 mg 24 Hour tablet 6.88USD tablet
    Altoprev 20 mg tablet 6.61USD tablet
    Mevacor 40 mg tablet 4.57USD tablet
    Altoprev 40 mg tablet 4.41USD tablet
    Lovastatin 40 mg tablet 4.36USD tablet
    Altoprev 10 mg 24 Hour tablet 3.,07USD tablet
    Mevacor 20 mg tablet 2.53USD tablet
    Lovastatin 20 mg tablet 2.42USD tablet
    Altocor 20 mg 24 Hour tablet 2.36USD tablet
    Apo-Lovastatin 40 mg Tablet 2.11USD tablet
    Co Lovastatin 40 mg Tablet 2.11USD tablet
    Mylan-Lovastatin 40 mg Tablet 2.11USD tablet
    Novo-Lovastatin 40 mg Tablet 2.,11USD tablet
    Pms-Lovastatin 40 mg Tablet 2.11USD tablet
    Ran-Lovastatin 40 mg Tablet 2.11USD tablet
    Ratio-Lovastatin 40 mg Tablet 2.11USD tablet
    Sandoz Lovastatin 40 mg Tablet 2.11USD tablet
    Mevacor 10 mg tablet 1.65USD tablet
    Lovastatin 10 mg tablet 1.37USD tablet
    Apo-Lovastatin 20 mg Tablet 1.,14USD tablet
    Co Lovastatin 20 mg Tablet 1.14USD tablet
    Mylan-Lovastatin 20 mg Tablet 1.14USD tablet
    Novo-Lovastatin 20 mg Tablet 1.14USD tablet
    Pms-Lovastatin 20 mg Tablet 1.14USD tablet
    Ran-Lovastatin 20 mg Tablet 1.14USD tablet
    Ratio-Lovastatin 20 mg Tablet 1.14USD tablet
    Sandoz Lovastatin 20 mg Tablet 1.,14USD tablet
    DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.

    Patents

    Properties

    State Solid Experimental Properties Predicted Properties

    Property Value Source
    Water Solubility 0.0243 mg/mL ALOGPS
    logP 4.,11 ALOGPS
    logP 3.9 ChemAxon
    logS -4.2 ALOGPS
    pKa (Strongest Acidic) 14.91 ChemAxon
    pKa (Strongest Basic) -2.8 ChemAxon
    Physiological Charge 0 ChemAxon
    Hydrogen Acceptor Count 3 ChemAxon
    Hydrogen Donor Count 1 ChemAxon
    Polar Surface Area 72.,83 Å2 ChemAxon
    Rotatable Bond Count 7 ChemAxon
    Refractivity 113.18 m3·mol-1 ChemAxon
    Polarizability 46.,/td>

    		ChemAxon
    Rule of Five Yes ChemAxon
    Ghose Filter Yes ChemAxon
    Veber’s Rule No ChemAxon
    MDDR-like Rule Yes ChemAxon

    Predicted ADMET Features

    Property Value Probability
    Human Intestinal Absorption + 0.,9452
    Blood Brain Barrier + 0.9287
    Caco-2 permeable – 0.5484
    P-glycoprotein substrate Substrate 0.7861
    P-glycoprotein inhibitor I Inhibitor 0.7046
    P-glycoprotein inhibitor II Inhibitor 0.8388
    Renal organic cation transporter Non-inhibitor 0.8299
    CYP450 2C9 substrate Non-substrate 0.,8333
    CYP450 2D6 substrate Non-substrate 0.9116
    CYP450 3A4 substrate Substrate 0.6868
    CYP450 1A2 substrate Non-inhibitor 0.9045
    CYP450 2C9 inhibitor Non-inhibitor 0.9291
    CYP450 2D6 inhibitor Non-inhibitor 0.923
    CYP450 2C19 inhibitor Non-inhibitor 0.9026
    CYP450 3A4 inhibitor Inhibitor 0.,796
    CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.8682
    Ames test Non AMES toxic 0.8475
    Carcinogenicity Non-carcinogens 0.9519
    Biodegradation Not ready biodegradable 0.8819
    Rat acute toxicity 2.0554 LD50, mol/kg Not applicable
    hERG inhibition (predictor I) Weak inhibitor 0.,7272
    hERG inhibition (predictor II) Non-inhibitor 0.7484
    ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties.,td> IC 50 (nM) 20 N/A N/A 1597859 IC 50 (nM) 20100 N/A N/A 21872367 IC 50 (nM) 30 N/A N/A 23570542 IC 50 (nM) 37 N/A N/A 1527791 IC 50 (nM) 50 N/A N/A 1656041 / 2296036

    • Details

    Binding Properties1., 3-hydroxy-3-methylglutaryl-coenzyme A reductase

    Kind Protein Organism Humans Pharmacological action

    Yes

    Actions

    Inhibitor

    General Function Nadph binding Specific Function Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including… Gene Name HMGCR Uniprot ID P04035 Uniprot Name 3-hydroxy-3-methylglutaryl-coenzyme A reductase Molecular Weight 97475.,155 Da

    1. Abe y, Suzuki T, C C, Iwamoto K, Hosobuchi M, Yoshikawa H: Molecular Cloning and characterization of an ML-236B (compactin) biosynthetic gene cluster in Penicillium citrinum. Mol Genet Genomics. 2002 Jul; 267 (5): 636-46. Epub 2002 Jun 28.
    2. Miyazaki a, Koieyama T, Shimada y, Kikuchi T, Nezu H, K K, Kasanuki N, Koga T: Effects of pravastatin sodium on mevalonate metabolism in common titosets. J Biochem. 2002 Sep; 132 (3): 395-400.,
    3. Buxbaum JD, Geoghagen NS, Friedhoff LT: la depleción de colesterol con concentraciones fisiológicas de una estatina disminuye la formación del péptido de Alzheimer amiloide Abeta. J Alzheimer Dis. 2001 Apr; 3 (2): 221-229.
    4. Baranova NA, Kreier VG, Egorov NS:. Antibiot Khimioter. 2002;47(4):3-6.
    5. Farina HG, Bublik DR, Alonso DF, Gomez de: Lovastatin altera la organización del citoesqueleto e inhibe la metástasis experimental de células de carcinoma mamario. Clin Exp Metástasis. 2002;19(6):551-9.
    6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res., 2002 Jan 1;30(1): 412-5.
    7. Podar K, Tai YT, Hideshima T, Vallet s, Richardson PG, Anderson KC: Emerging therapies for multiple myeloma. Experto En Drogas Opin Emerg. 2009 Mar;14(1): 99-127. doi: 10.1517 / 14728210802676278 .
    8. Dimitroulakos J, Marhin WH, Tokunaga J, Irish J, Gullane P, Penn LZ, Kamel-Reid s: microarray and biochemical analysis of lovastatin-induced apoptosis of squamous cell carcinomas. Neoplasia. 2002 Jul-Aug;4(4): 337-46.,

    Binding Properties

    ×

    Property Measurement pH Temperature (°C)
    Kd (nM) 12900 N/A N/A 23339734

    Details

    Binding Properties2., Integrin alpha-L

    Kind Protein Organism Humans Pharmacological action

    Unknown

    Actions

    Inhibitory allosteric modulator

    General Function Metal ion binding Specific Function Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated … Gene Name ITGAL Uniprot ID P20701 Uniprot Name Integrin alpha-L Molecular Weight 128768.,495 Da

    1. Kallen J, Welzenbach K, Ramage P, Geyl D, Kriwacki R, Legge G, Cottens s, Weitz-Schmidt G, Hommel U: Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain. J Mol Biol. 1999 Sep 10; 292 (1): 1-9.
    2. Weitz-Schmidt G, Welzenbach K, Brinkmann V, Kamata T, Kallen J, Bruns C, Cottens s, Takada y, Hommel U: Las estatinas inhiben selectivamente el antígeno-1 de la función leucocitaria al unirse a un nuevo sitio regulador de la integrina. Nat Med. 2001 Jun; 7 (6): 687-92. doi: 10.1038 / 89058.
    3. Liao JK, Laufs U: efectos Pleiotrópicos de las estatinas., Annu Rev Pharmacol Toxicol. 2005;45:89-118. doi: 10.1146 / annurev.pharmtox.45.120403.095748.,

    Binding Properties

    ×

    Property Measurement pH Temperature (°C)
    IC 50 (nM) 25933 N/A N/A 23570542

    Details

    Binding Properties3., Histona deacetilasa 2

    tipo de proteína organismo humano acción farmacológica

    no

    acciones

    otro

    función General de unión al factor de transcripción función específica responsable de la desacetilación de residuos de lisina en la parte N-terminal de las histonas centrales (H2A, H2B, H3 y H4). La desacetilación de histonas da una Etiqueta para la represión epigenética y juega un impo… Nombre del gen HDAC2 ID de UniProt Q92769 nombre de UniProt histona deacetilasa 2 peso Molecular 55363.,855 Da

    1. Lin YC, Lin JH, Chou CW, Chang YF, YEH SH, Chen CC: Las estatinas aumentan la p21 a través de la inhibición de la actividad de la histona deacetilasa y la liberación de HDAC1/2 asociado al promotor. Cancer Res. 2008 Apr 1; 68(7): 2375-83. doi: 10.1158 / 0008-5472.CAN-07-5807.,

    Enzymes

    Kind Protein Organism Humans Pharmacological action

    Unknown

    Actions

    Substrate
    Inhibitor

    General Function Vitamin d3 25-hydroxylase activity Specific Function Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react… Gene Name CYP3A4 Uniprot ID P08684 Uniprot Name Cytochrome P450 3A4 Molecular Weight 57342.,67 Da

    1. Rendic s: Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34 (1-2): 83-448.
    2. Hong SP, Yang JS, han JY, ha Si, Chung JW, Koh YY, Chang KS, Choi DH: efectos de la lovastatina sobre la farmacocinética de diltiazem y su principal metabolito, desacetyldiltiazem, en ratas: posible papel de la inhibición del citocromo P450 3A4 y la glicoproteína P Por lovastatina. J Pharm Pharmacol. 2011 Jan; 63 (1): 129-35.,
    3. Kitzmiller JP, Mikulik EB, Dauki AM, Murkherjee C, Luzum JA: Pharmacogenomics of statins: understanding susceptibility to adverse effects. Pharmgenomics Pers Med. 2016 Oct 3;9: 97-106. doi: 10.2147 / PGPM.S86013. eCollection 2016.
    4. Neuvonen PJ, Backman JT, Niemi M: comparación farmacocinética de las estatinas potenciales de venta libre simvastatina, lovastatina, fluvastatina y pravastatina. Clin Pharmacokinet. 2008;47(7):463-74. doi: 10.2165 / 00003088-200847070-00003.,
    5. Flockhart Tabla de Interacciones medicamentosas
    6. TABLETAS de MEVACOR® (LOVASTATIN) La FDA de la ETIQUETA
    7. la FDA Label – Lovastatina
    8. ministerio de Salud de Canadá Monografía – Lovastatina

    Tipo de Proteína Organismo de los seres Humanos acción Farmacológica

    Desconocido

    Acciones

    Sustrato

    General de la Función de la Proteína homodimerización de la actividad Específica de la Función Tiene una baja actividad hacia la organofosforados paraxon aromáticos y ácidos carboxílicos ésteres. Hidroliza rápidamente lactonas como profármacos de estatinas (por ejemplo, lovastatina)., Hidroliza lactonas aromáticas y 5 -… Nombre del gen PON3 UniProt ID Q15166 nombre de UniProt Serum Paraoxonase / lactonase 3 peso Molecular 39607.185 da

    1. Draganov DI, Stetson PL, Watson CE, Billecke SS, La Du BN: Rabbit serum PARAOXONASE 3 (PON3) es una lactonasa asociada a lipoproteínas de alta densidad y protege la lipoproteína de baja densidad contra la oxidación. J Biol Chem. 2000 Oct 27; 275(43): 33435-42.,

    tipo de proteína organismo humano acción farmacológica

    Desconocido

    acciones

    sustrato

    función General actividad de la hidroxilasa esteroide función específica los citocromos P450 son un grupo de monooxigenasas hemo-tiolato. En los microsomas hepáticos, esta enzima está involucrada en una vía de transporte de electrones dependiente del NADPH. Se oxida una variedad de estructuralmente ONU… Nombre del gen CYP2C8 identificación de Uniprot P10632 nombre de UniProt citocromo P450 2C8 peso Molecular 55824.,275 da

    1. Tornio a, Pasanen MK, Laitila J, Neuvonen PJ, Backman JT: comparación de los inhibidores de la 3-hidroxi-3-metilglutaril coenzima A (HMG-CoA) reductasa (estatinas) como inhibidores del citocromo P450 2C8. Basic Clin Pharmacol Toxicol. 2005 Aug; 97(2): 104-8.
    2. Walsky RL, Gaman EA, Obach RS: examen de 209 fármacos para la inhibición del citocromo P450 2C8. J Clin Pharmacol. 2005 Jan; 45(1): 68-78.
    3. Kitzmiller JP, Mikulik EB, Dauki AM, Murkherjee C, Luzum JA: Pharmacogenomics of statins: understanding susceptibility to adverse effects. Pharmgenomics Pers Med., 2016 Oct 3;9: 97-106. doi: 10.2147 / PGPM.S86013. eCollection 2016.
    4. Neuvonen PJ, Backman JT, Niemi M: comparación farmacocinética de las estatinas potenciales de venta libre simvastatina, lovastatina, fluvastatina y pravastatina. Clin Pharmacokinet. 2008;47(7):463-74. doi: 10.2165 / 00003088-200847070-00003.,

    Kind Protein Organism Humans Pharmacological action

    No

    Actions

    Substrate

    General Function Steroid binding Specific Function UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the… Gene Name UGT1A1 Uniprot ID P22309 Uniprot Name UDP-glucuronosyltransferase 1-1 Molecular Weight 59590.,91 da

    1. Kitzmiller JP, Mikulik EB, Dauki AM, Murkherjee C, Luzum JA: Pharmacogenomics of statins: understanding susceptibility to adverse effects. Pharmgenomics Pers Med. 2016 Oct 3;9: 97-106. doi: 10.2147 / PGPM.S86013. eCollection 2016.,
    2. Public presentations

    Kind Protein Organism Humans Pharmacological action

    Unknown

    Actions

    Substrate

    General Function Retinoic acid binding Specific Function UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative reg… Gene Name UGT1A3 Uniprot ID P35503 Uniprot Name UDP-glucuronosyltransferase 1-3 Molecular Weight 60337.,835 da

    1. Kitzmiller JP, Mikulik EB, Dauki AM, Murkherjee C, Luzum JA: Pharmacogenomics of statins: understanding susceptibility to adverse effects. Pharmgenomics Pers Med. 2016 Oct 3;9: 97-106. doi: 10.2147 / PGPM.S86013. eCollection 2016.,
    2. Public presentations

    Kind Protein Organism Humans Pharmacological action

    Unknown

    Actions

    Substrate

    General Function Glucuronosyltransferase activity Specific Function UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.Its unique specificity for 3,4-catechol estrogens and estriol su… Gene Name UGT2B7 Uniprot ID P16662 Uniprot Name UDP-glucuronosyltransferase 2B7 Molecular Weight 60694.,12 Da

    1. Prueksaritanont T, Subramanian R, Fang X, Ma B, Qiu y, Lin JH, Pearson PG, Baillie TA: Glucuronidation of statins in animals and humans: a novel mechanism of statin lactonization. Dispos De Metab De Drogas. 2002 May; 30 (5): 505-12.
    2. Kitzmiller JP, Mikulik EB, Dauki AM, Murkherjee C, Luzum JA: Pharmacogenomics of statins: understanding susceptibility to adverse effects. Pharmgenomics Pers Med. 2016 Oct 3;9: 97-106. doi: 10.2147 / PGPM.S86013. eCollection 2016.,

    Kind Protein Organism Humans Pharmacological action

    Unknown

    Actions

    Substrate

    General Function Steroid hydroxylase activity Specific Function Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and im… Gene Name CYP2C19 Uniprot ID P33261 Uniprot Name Cytochrome P450 2C19 Molecular Weight 55930.,545 da

    1. Kitzmiller JP, Mikulik EB, Dauki AM, Murkherjee C, Luzum JA: Pharmacogenomics of statins: understanding susceptibility to adverse effects. Pharmgenomics Pers Med. 2016 Oct 3;9: 97-106. doi: 10.2147 / PGPM.S86013. eCollection 2016.

    Transportistas

    Details1., Serum albumin

    Kind Protein Organism Humans Pharmacological Action

    no

    Actions

    Substrate

    función General de unión de sustancias tóxicas función específica la albúmina sérica, la proteína principal del plasma, tiene una buena capacidad de unión para agua, Ca (2+), Na (+), K (+), ácidos grasos, hormonas, bilirrubina y medicamentos. Su función principal es la regulación del coloide… Gen nombre ALB UniProt ID P02768 nombre UniProt albúmina sérica peso Molecular 69365.,94 Da

    1. Lennernas H, Fager G: farmacodinámica y farmacocinética de los inhibidores de la HMG-CoA reductasa. Similitudes y diferencias. Clin Pharmacokinet. 1997 May;32 (5): 403-25. doi: 10.2165 / 00003088-199732050-00005.,iv>
      IC 50 (nM) 10000 N/A N/A 15616150 IC 50 (nM) 114400 N/A N/A 11716514 IC 50 (nM) 26000 N/A N/A 11474784 IC 50 (nM) 32700 N/A N/A 11716514 IC 50 (nM) 67000 N/A N/A 11474784

    Details

    Binding Properties1., P-glycoprotein 1

    Kind Protein Organism Humans Pharmacological action

    Unknown

    Actions

    Inhibitor

    General Function Xenobiotic-transporting atpase activity Specific Function Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. Gene Name ABCB1 Uniprot ID P08183 Uniprot Name Multidrug resistance protein 1 Molecular Weight 141477.,255 da

    1. Wang e, Casciano CN, Clement RP, Johnson WW: inhibidores de la HMG-CoA reductasa (estatinas) caracterizados como inhibidores directos de la glicoproteína P. Pharm Res. 2001 Jun; 18 (6): 800-6.
    2. Wang EJ, Casciano CN, Clement RP, Johnson WW: Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochem Biophys Res Commun. 2001 Nov 30; 289 (2): 580-5.,
    3. Kim RB, Wandel C, Leake B, Cvetkovic M, Fromm MF, Dempsey PJ, Roden MM, Belas F, Chaudhary AK, Roden DM, Wood AJ, Wilkinson GR: Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein. Pharm Res. 1999 Mar;16 (3): 408-14.
    4. Choi DH, Chung JH, Choi JS: interacción farmacocinética entre lovastatina oral y verapamilo en sujetos sanos: papel de la inhibición de la glicoproteína P Por lovastatina. Eur J Clin Pharmacol. 2010 Mar; 66(3): 285-90. doi: 10.1007 / s00228-009-0757-X. Epub 2009 Dec 12.,
    5. Neuvonen PJ, Backman JT, Niemi M: comparación farmacocinética de las estatinas potenciales de venta libre simvastatina, lovastatina, fluvastatina y pravastatina. Clin Pharmacokinet. 2008;47(7):463-74. doi: 10.2165 / 00003088-200847070-00003.,

    tipo de proteína organismo humano acción farmacológica

    Desconocido

    acciones

    inhibidor
    función General actividad transportadora transmembrana de aniones orgánicos independientes de sodio función específica Media el transporte independiente de aniones orgánicos como sulfobromoftaleína (BSP) y conjugado (taurocolato) y ácidos biliares no conjugados (colados) (por similitud). Inhibir selectivamente…, Nombre del gen SLCO1A2 ID de Uniprot P46721 nombre de UniProt portador de soluto transportador de aniones orgánicos miembro de la familia 1A2 peso Molecular 74144.105 Da
    1. Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB: los transportadores de oatp y P-glicoproteína median la captación celular y la excreción de fexofenadina. Dispos De Metab De Drogas. 1999 Aug; 27 (8): 866-71.
    2. Hsiang B, Zhu Y, Wang Z, Wu y, Sasseville V, Yang WP, Kirchgessner TG: a novel human hepatic organic anion transporting polypeptide (oatp2)., Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters. J Biol Chem. 1999 Dec 24;274(52):37161-8.,

    Binding Properties

    ×

    Property Measurement pH Temperature (°C)
    IC 50 (nM) 28000 N/A N/A 15616150

    Details

    Binding Properties3., Solute carrier organic anion transporter family member 1B1

    Kind Protein Organism Humans Pharmacological action

    Unknown

    Actions

    Substrate
    Inhibitor

    General Function Sodium-independent organic anion transmembrane transporter activity Specific Function Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostagland…, Gene Name SLCO1B1 UniProt ID Q9Y6L6 UniProt Name solute carrier organic anion transporter family member 1B1 Molecular Weight 76447.99 da
    1. Hsiang B, Zhu y, Wang Z, Wu y, Sasseville V, Yang WP, Kirchgessner TG: a novel human organic anion transporting polypeptide (oatp2). La identificación de un hígado humano específico de aniones orgánicos transporte de polipéptido y la identificación de rata y humano de la hidroximetilglutaril-CoA reductasa transportadores. J Biol Chem. 1999 Dec 24; 274 (52): 37161-8.,
    2. Sandhu P, Lee W, Xu X, Leake BF, Yamazaki M, Stone JA, Lin JH, Pearson PG, Kim RB: hepatic uptake of the novel antifungal agent caspofungin. Dispos De Metab De Drogas. 2005 May; 33 (5): 676-82. Epub 2005 Feb 16.
    3. Kunze a, Huwyler J, Camenisch G, Poller B: Prediction of organic anion-transporting polypeptide 1B1 – and 1B3-mediated hepatic uptake of statins based on transporter protein expression and activity data. Dispos De Metab De Drogas. 2014 Sep; 42(9): 1514-21. doi: 10.1124 / dmd.114.058412. Epub 2014 Jul 2.,
    4. Tornio a, Vakkilainen J, Neuvonen M, Backman JT, Neuvonen PJ, Niemi m: El polimorfismo SLCO1B1 afecta notablemente la farmacocinética del ácido de lovastatina. Pharmacogenet Genomics. 2015 Aug; 25(8): 382-7. doi: 10.1097 / FPC.0000000000000148.
    5. Zhao G, Liu M, Wu X, Li G, Qiu F, Gu J, Zhao L: efecto de los polimorfismos en CYP3A4, PPARA, NR1I2, NFKB1, ABCG2 y SLCO1B1 sobre la farmacocinética de lovastatina en voluntarios sanos Chinos. Farmacogenómica. 2017 Jan;18 (1): 65-75. doi: 10.2217 / pgs.16.31. Epub 2016 Dic 14.,
    6. Xiang Q, Chen SQ, Ma LY, Hu K, Zhang Z, Mu GY, Xie QF, Zhang XD, Cui YM: Association between SLCO1B1 T521C polymorphism and risk of statin-induced myopathy: a meta-analysis. Pharmacogenomics J. 2018 Dec;18(6):721-729. doi: 10.1038/s41397-018-0054-0. Epub 2018 Sep 24.

    Kind Protein Organism Humans Pharmacological action

    Unknown

    Actions

    Substrate

    General Function Organic anion transmembrane transporter activity Specific Function Mediates hepatobiliary excretion of numerous organic anions., Puede funcionar como un transportador de cisplatino celular. Gene Name ABCC2 UniProt ID Q92887 nombre UniProt canalicular multiespecífico organic anion transporter 1 peso Molecular 174205.64 da
    1. Ellis LC, Hawksworth GM, Weaver RJ: ATP-dependent transport of statins by human and rat MRP2/Mrp2. Toxicol Appl Pharmacol. 2013 Jun 1; 269(2): 187-94. doi: 10.1016 / j.taap.2013.03.019. Epub 2013 Apr 2.
    2. Kitzmiller JP, Mikulik EB, Dauki AM, Murkherjee C, Luzum JA: Pharmacogenomics of statins: understanding susceptibility to adverse effects. Pharmgenomics Pers Med., 2016 Oct 3;9: 97-106. doi: 10.2147 / PGPM.S86013. eCollection 2016.

    especie proteína organismo humano acción farmacológica

    no

    acciones

    sustrato

    función General actividad transportadora función específica implicada en la secreción ATP-dependiente de sales biliares en el canalículo de los hepatocitos. Nombre del gen ABCB11 ID de UniProt O95342 nombre de UniProt Bomba de exportación de sal biliar peso Molecular 146405.,83 Da

    1. Pedersen JM, Matsson P, Bergstrom CA, Hoogstraate J, Noren a, LeCluyse el, Artursson P: Early identification of clinically relevant drug interactions with the human bile Salt export pump (bsep/ABCB11). Toxicol Sci. 2013 Dec;136(2): 328-43. doi: 10.1093 / toxsci / kft197. Epub 2013 Sep 6.,

    Kind Protein Organism Humans Pharmacological action

    Unknown

    General Function Sodium-independent organic anion transmembrane transporter activity Specific Function Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost. Gene Name SLCO2B1 Uniprot ID O94956 Uniprot Name Solute carrier organic anion transporter family member 2B1 Molecular Weight 76709.,98 da

    1. Kitzmiller JP, Mikulik EB, Dauki AM, Murkherjee C, Luzum JA: Pharmacogenomics of statins: understanding susceptibility to adverse effects. Pharmgenomics Pers Med. 2016 Oct 3;9: 97-106. doi: 10.2147 / PGPM.S86013. eCollection 2016.,

    Kind Protein Organism Humans Pharmacological action

    Unknown

    General Function Sodium-independent organic anion transmembrane transporter activity Specific Function Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotre… Gene Name SLCO1B3 Uniprot ID Q9NPD5 Uniprot Name Solute carrier organic anion transporter family member 1B3 Molecular Weight 77402.,175 da

    1. Kitzmiller JP, Mikulik EB, Dauki AM, Murkherjee C, Luzum JA: Pharmacogenomics of statins: understanding susceptibility to adverse effects. Pharmgenomics Pers Med. 2016 Oct 3;9: 97-106. doi: 10.2147 / PGPM.S86013. eCollection 2016.

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