May be potentiated by pramlintide acetate, insulin, ACE inhibitors, H2 receptor antagonists, fibrates, propoxyphene, pentoxifylline, somatostatin analogs, anabolic steroids and androgens, cyclophosphamide, phenyramidol, guanethidine, fluconazole, sulfinpyrazone, tetracyclines, clarithromycin, disopyramide, quinolones, NSAIDs, highly protein bound drugs (eg, fluoxetine), oral miconazole (possibly), salicylates, sulfonamides, warfarin, chloramphenicol, probenecid, MAOIs., May be antagonized by danazol, glucagon, somatotropin, protease inhibitors, atypical antipsychotics, barbiturates, diazoxide, laxatives, rifampin, thiazides, diuretics, corticosteroids, phenothiazines, thyroid products, phenytoin, niacin, sympathomimetics, isoniazid, estrogens, oral contraceptives. Monitor closely for hypoglycemia when concomitant drugs that affect glucose metabolism and upon withdrawal. Caution with CYP2C9 inhibitors (eg, fluconazole) or inducers (eg, rifampin). May be potentiated or antagonized by β-blockers, clonidine, reserpine, alcohol., Pode ser antagonizado pelo colesevelam; administrar glimepirida ≥4hrs antes do colesevelam. Foram notificadas reacções de dissulfiram com outras sulfonilureias. Monitorize durante 1-2 semanas se for transferido de sulfonilureias de acção prolongada.