Ver contra-indicações. Os aumentos de ALT com o regime de VHC de ombitasvir/paritaprevir/ritonavir, com ou sem dasabuvir; interromper Orto Tri-Cicleno antes de iniciar o regime de VHC e reiniciar 2wks após a conclusão. Pode ser antagonizado pela fenitoína, barbitúricos, carbamazepina, bosentano, felbamato, griseofulvin, oxcarbazepina, rifampicina, topiramato, rifabutina, rufinamida, aprepitant, hipericão; utilize contracepção de reserva., May be potentiated by atorvastatin, rosuvastatin, acetaminophen, ascorbic acid, or CYP3A4 inhibitors (eg, itraconazole, ketoconazole, voriconazole, fluconazole, grapefruit juice). May be affected by HIV protease inhibitors. Concomitant colesevelam; give 4hrs apart. May antagonize acetaminophen, temazepam, salicylic acid, morphine, clofibric acid, lamotrigine. May potentiate cyclosporine, prednisolone, theophylline, tizanidine, voriconazole. May need dose adjustment of thyroid hormones., May affect lab tests (eg, coagulation factors, triglycerides, lipids, glucose tolerance, binding proteins, hormone binding globulins, serum folate).