Ver Contraindicaciones. Elevaciones de ALT con el régimen de VHC ombitasvir/paritaprevir/ritonavir, con o sin dasabuvir; suspender Ortho Tri-Cyclen To antes de iniciar el régimen de VHC y reiniciar 2 semanas después de finalizar. Puede ser antagonizado por fenitoína, barbitúricos, carbamazepina, bosentan, felbamato, griseofulvina, oxcarbazepina, rifampicina, topiramato, rifabutina, rufinamida, aprepitant, hierba de San Juan; use anticoncepción de respaldo., May be potentiated by atorvastatin, rosuvastatin, acetaminophen, ascorbic acid, or CYP3A4 inhibitors (eg, itraconazole, ketoconazole, voriconazole, fluconazole, grapefruit juice). May be affected by HIV protease inhibitors. Concomitant colesevelam; give 4hrs apart. May antagonize acetaminophen, temazepam, salicylic acid, morphine, clofibric acid, lamotrigine. May potentiate cyclosporine, prednisolone, theophylline, tizanidine, voriconazole. May need dose adjustment of thyroid hormones., May affect lab tests (eg, coagulation factors, triglycerides, lipids, glucose tolerance, binding proteins, hormone binding globulins, serum folate).