May be potentiated by pramlintide acetate, insulin, ACE inhibitors, H2 receptor antagonists, fibrates, propoxyphene, pentoxifylline, somatostatin analogs, anabolic steroids and androgens, cyclophosphamide, phenyramidol, guanethidine, fluconazole, sulfinpyrazone, tetracyclines, clarithromycin, disopyramide, quinolones, NSAIDs, highly protein bound drugs (eg, fluoxetine), oral miconazole (possibly), salicylates, sulfonamides, warfarin, chloramphenicol, probenecid, MAOIs., May be antagonized by danazol, glucagon, somatotropin, protease inhibitors, atypical antipsychotics, barbiturates, diazoxide, laxatives, rifampin, thiazides, diuretics, corticosteroids, phenothiazines, thyroid products, phenytoin, niacin, sympathomimetics, isoniazid, estrogens, oral contraceptives. Monitor closely for hypoglycemia when concomitant drugs that affect glucose metabolism and upon withdrawal. Caution with CYP2C9 inhibitors (eg, fluconazole) or inducers (eg, rifampin). May be potentiated or antagonized by β-blockers, clonidine, reserpine, alcohol., Poate fi antagonizat de colesevelam; administrați glimepiridă ≥4 ore înainte de colesevelam. Au fost raportate reacții de Disulfiram în cazul altor sulfoniluree. Monitorizați timp de 1-2 săptămâni dacă treceți de la sulfoniluree cu acțiune lungă.